Yimon Aye

Howard Milstein Faculty Fellow and Assistant Professor

Overview

Note to applicants for positions in the Aye Lab: Following lab promotion, we are very excited to be moving to join EPFL in the near future Business will be uninterrupted as almost all of the team members are coming along. We are happy to have spent our formative years at Cornell and Weill Cornell Medicine.

Innovation and applications of novel tools to interrogate cell signaling; Mechanisms of proteins/pathways involved in genome protection and drugs that tap into these pathways. Please visit our lab for more information.

Research Focus

The (established: July 2012) exploits a unique blend of chemical biology methods development, mechanistic biochemistry, mammalian cell biology as in vitro research toolkit and worm and fish as in vivo models.

Publications

From the Aye Lab (est. July 2012)

(^*correspondence author)

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Original Research
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Yuan Fu, Marcus J. C. Long, Somsinee Wisitpitthaya, Huma Inayat, Timothy M. Pierpont, Islam M. Elsaid, Jordana C. Bloom, Joaquin Ortega, Robert S. Weiss, and Yimon Aye*

Nature Chemical Biology 2018 Just Accepted

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Original Research
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Yi Zhao, Marcus J. C. Long, Yiran Wang, Sheng Zhang, and Yimon Aye*

ACS Central Science 2018 4, 246–259

* Selected as Hero Image of the Journal (April 2018)

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Problems and Paradigms
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Jesse R. Poganik, Marcus J. C. Long, and Yimon Aye*

BioEssays 2018 Just Accepted (doi:10.1002/bies.201700240)

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Original Research
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Sanjna L. Surya, Marcus J. C. Long, Daniel A. Urul, Yi Zhao, Emily J. Mercer, Islam M. Elsaid, Todd Evans, and Yimon Aye*

ACS Chemical Biology 2018 Just Accepted (doi: 10.1021/acschembio)

* Invited contribution to "Biosensors" special issue

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Protocols
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Alexandra Van Hall-Beauvais, Yi Zhao, Daniel A. Urul, Marcus J. C. Long, and Yimon Aye*

"Single-protein-specific redox targeting in live mammalian cells and C. elegans"

Current Protocols in Chemical Biology 2018 Just Accepted (doi:10.1002/cpch.43)

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Original Research
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Marcus J. C. Long, Daniel A. Urul, Shivansh Chawla, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Yiran Wang, and Yimon Aye*

Biochemistry 2018 57, 216–220

* Invited contribution to "Future of Biochemistry" special issue

* Selected as an ACS Editors' Choice article.

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Original Research
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Marcus J. C. Long, Hong-Yu Lin, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye*

Cell Chemical Biology 2017 24, 944–957

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Perspective
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Marcus J. C. Long, and Yimon Aye*

Cell Chemical Biology 2017 24, 787–800

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Original Research
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Marcus J. C. Long, Saba Parvez, Yi Zhao, Yiran Wang, Sanjna L. Surya, and Yimon Aye*

Nature Chemical Biology 2017 13, 333–338

*Highlighted for “News & Views”: Nature Chemical Biology 2017 13, 244–245

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Review Article
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Marcus J. C. Long, Souradyuti Ghosh, Jesse R. Poganik, and Yimon Aye*

“.”

ACS Chemical Biology 2017 12, 586–600

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Original Research
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Saba Parvez, Marcus J. C. Long, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye*

“”

Nature Protocols 2016 11, 2328–2356

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Perspective
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Marcus J. C. Long, and Yimon Aye*

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ACS Chem Res Toxicol 2016 29, 1575–1582

* Contributed as part of 2016 ACS CRT Young Investigator Award to Y.A.

* Selected as an ACS Editors' Choice article.

* Selected for Journal Cover Art.

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Original Research
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Somsinee Wisitpatthaya, Yi Zhao, Marcus J. C. Long, Minxing Li, William A. Blessing, Elaine A. Fletcher, Robert S. Weiss, and Yimon Aye*

“”

ACS Chemical Biology 2016 11, 2021–2032

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Perspective
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Marcus J. C. Long, Jesse R. Poganik, and Yimon Aye* “”

J Am Chem Soc 2016, 138, 3610–3622

*Selected as a JACS Spotlights Article – 2016, 138, 4269

* The ACS LiveSlides Open Access Article

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Original Research
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Hong-Yu Lin, Joseph A. Haegele, Michael T. Disare, and Yimon Aye* “”

J Am Chem Soc (Full Article) 2015, 137, 6232–6244

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Original Research
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Saba Parvez, Yuan Fu, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu and Yimon Aye*

“”

J Am Chem Soc (Communication) 2015, 137, 10–13

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Mini Review
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Yimon Aye*, Minxing Li, Marcus J. C. Long and Robert Weiss* (*, co-corresponding authors)

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Oncogene (Mini Review) 2015, 34, 2011

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Original Research
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Yuan Fu, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing and Yimon Aye*

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ChemBioChem (Full Article) 2014, 15, 2598–2604

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Original Research
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Yuan Fu, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing and Yimon Aye*

“”

Biochemistry (Full Article) 2013, 52, 7050–7059

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Original Research
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Xinqiang Fang, Yuan Fu, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez and Yimon Aye*

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J Am Chem Soc (Communication) 2013, 135, 14496–14499

Postdoctoral (Aug 2009 - June 2012)

Original research:

“” Yimon Aye, Marcus J. C. Long and JoAnne Stubbe* J Biol Chem 2012, 287, 35768.
“” Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias, and JoAnne Stubbe* Chem Biol 2012, 19, 799.
“” Yimon Aye and JoAnne Stubbe* Proc Natl Acad Sci USA 2011 direct submission, 108, 9815.

Predoctoral (Jan 2005 - Jun 2009)

Independent review article:

“” Marcus J. Curtis-¬Long and Yimon Aye*; Chemistry, A European Journal 2009, 15, 5402.

Original research:

“” Richard J. Staples* and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49.
“” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2007, 129, 9606.
“” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2006, 128, 11034.
“” David A. Evans*, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071.
“” Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald*; Proceedings to the National Academy of �鶹��Ƶ USA, 2004, 101, 5821.

In the news

Education

Damon Runyon Postdoc Fellow, Massachusetts Institute of Technology (2009-2012)
PhD, Harvard University (2009)
M.Chem, University of Oxford (2004)
B.Chem, University of Oxford (2003)

Departments and programs

Chemistry and Chemical Biology

Affiliated Colleges

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Keywords

Selected Honors: Beckman Young Investigator (2014); NSF CAREER (2014); NIH Director's New Innovator (2014); Sloan Fellowship (2016); American Chemical Society CRT Young Investigator (2016); American Chemical Society WCC Rising Star Chemist (2016); International Chemical Biology Society Rising Star Chemical Biologist (2016); Office of Naval Research Young Investigator (2017); Pershing Square Sohn Prize in Cancer Research (2017); American Chemical Society Buck-Whitney Award (2017)

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