Overview
The Crane group studies structure, function and mechanism of protein systems that underlie signal transduction. Of particular emphasis are processes mediated by redox and photochemistry and those dependent on highly cooperative macromolecular assemblies. Projects include understanding circadian clock light sensors, bacterial transmembrane signaling, nitric oxide enzymology and general aspects of protein electron transfer.
Research Focus
- Understanding interactions among proteins, electrons, and photons
- How metalloenzymes stabilize transient intermediates during catalysis
- How protein structure controls long-range electron transfer
- How photo and redox processes are used in biological information transfer
- Combine genetic and chemical manipulation of proteins, atomic-resolution structure determination, and novel photochemically triggered experiments in single crystals
- Understanding How Structure Controls Electron Transfer and Activated States in Metalloenzymes
- Bacterial Nitric Oxide Synthases:
- Light and Redox Sensing
- Bacterial Chemotaxis
Publications
- Vaidya AT, Chen CH, Dunlap JC, Loros JJ, Crane BR. Sci Signal. 2011, 4
- Paul K, Gonzalez-Bonet G, Bilwes AM, Crane BR, Blair D. EMBO J. 2011, 30, 2962-71.
- Airola MV, Watts KJ, Bilwes AM, Crane BR. Structure 2010, 18, 436-48.
- Bhatnagar J, Borbat PP, Pollard AM, Bilwes AM, Freed JH, Crane BR. Biochemistry 2010, 49, 3824-41.
- Patel BA, Moreau M, Widom J, Chen H, Yin L, Hua Y, Crane BR. Proc Natl Acad Sci U S A 2009, 106, 18183-8.
- Zoltowski BD, Vaccaro B, Crane BR. Nat Chem Biol. 2009, 5, 827-34.
- Zoltowski, B.D., Schwerdtfeger, C., Widom, J. Loros, J.J., Bilwes, A. M., Dunlap, J., C. & Crane, B.R. . Science, 2007, 316 1054-1057.
- Park, S. Y., Borbat, P. P., Gonzalez-Bonet, G., Bhatnagar, J., Freed, J. H., Bilwes, A. M. & Crane, B. R. . Nat. Struct. Mol. Biol., 2006, 13, 400-407.
- Chao, X., Muff, T., Park, S., Zhang, S., Pollard, A. M., Ordal, G., Bilwes, A. M. & Crane, B.R. . Cell, 2006, 124, 561-571.
- Kang, S. A. & Crane, B.R. . Proc. Natl. Acad. Sci. USA, 2005, 102, 15465-15470.
- Kers, J. A., Wach, M. J., Krasnoff, S. B., Widom, J., Cameron, K. D., Bukhalid, R. A., Gibson, D. M., Crane, B. R. & Loria, R. . Nature, 2004, 429, 79-82.
In the news
- New research sheds light on how circadian rhythms work
- Taylor retires from role leading A&S administration
- Glass blower crafts intricate creations for Cornell scientists
- Chemistry summer program = research + confidence
- Chemistry students offer summer session for peers
- Tom Ruttledge, retired chemistry lecturer, dies at 55
- Innovations in chemistry education help undergrads
- Nine projects receive undergrad engaged research funding
